Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants
| Autor: | Hidemi Ito, Yukihide Momozawa, Daisaku Nishimoto, Masayuki Murata, Kenji Takeuchi, Yohko Nakamura, Takashi Tamura, Asahi Hishida, Hiroaki Ikezaki, Ippei Shimoshikiryo, Yora Nindita, Kenji Wakai, Sakurako Katsuura-Kamao, Mako Nagayoshi, Yuichiro Nishida, Etsuko Ozaki, Kokichi Arisawa, Keitaro Matsuo, Rie Ibusuki, Rieko Okada, Megumi Hara, Takahiro Otani, Kiyonori Kuriki, Haruo Mikami, Masahiro Nakatochi, Sadao Suzuki, Keiichi Shimatani, Toshiro Takezaki, Michiaki Kubo, Teruhide Koyama, Naoyuki Takashima, Naoko Miyagawa |
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| Rok vydání: | 2023 |
| Předmět: |
Apolipoprotein E
education.field_of_study Epidemiology Cholesterol business.industry Population nutritional and metabolic diseases Genome-wide association study Single-nucleotide polymorphism General Medicine Population based chemistry.chemical_compound chemistry Attributable risk Cohort Medicine lipids (amino acids peptides and proteins) education business Demography |
| Zdroj: | Journal of Epidemiology. 33:193-200 |
| ISSN: | 1349-9092 0917-5040 |
| Popis: | BACKGROUND Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C. METHODS Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P < 5 × 10-8) were selected from the GWAS catalog, and seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF). RESULTS We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively. CONCLUSIONS The present study showed that the population-based impact of genomic factor CETP rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking. |
| Databáze: | OpenAIRE |
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