The relation of coronary and peripheral arterial disease to the severity of femoral atherosclerosis in hypercholesterolaemia
| Autor: | Göran Stenport, Jörgen Mölgaard, Claes Lassvik, Lott Bergstrand, U. Erikson, S. Nilsson, Lennart Kaijser, Ingar Holme, Jan Johansson, A. G. Olsson, Göran Walldius |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Arteriosclerosis Hypercholesterolemia Probucol Arterial Occlusive Diseases Coronary Disease Femoral artery Severity of Illness Index Coronary artery disease medicine.artery Internal medicine Internal Medicine Humans Medicine Myocardial infarction business.industry Vascular disease Abdominal aorta Angiography Middle Aged medicine.disease Intermittent claudication Femoral Artery Coronary arteries Cross-Sectional Studies medicine.anatomical_structure Cardiology Female Radiology medicine.symptom business medicine.drug |
| Zdroj: | Journal of Internal Medicine. 236:367-375 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1111/j.1365-2796.1994.tb00812.x |
| Popis: | Objectives. The extent of atherosclerosis in the superficial femoral artery and the severity of arterial disease in the aorto-iliac and femoro-popliteal arterial districts were related to clinical diagnosis of coronary and peripheral atherosclerosis in hypercholesterolaemic patients. Design. The study constitutes baseline cross-sectional data of a randomized double-blind clinical trial on Probucol, using both computer based and visual estimations of angiographies as endpoints. Subjects. Two hundred and ninety men and women (mean age 54 years) with hypercholesterolaemia. Main outcome measures. Atherosclerosis was estimated with arteriographies. Lumen volume and edge roughness (vessel inner wall irregularity) of a 20 cm segment of the femoral artery were estimated by computer. A visual atherosclerosis score of the abdominal aorta to the popliteal arteries was made on both sides. Results. Patients with peripheral arterial disease had significantly more advanced disease according to all three angiographic variables than those without symptoms of peripheral vascular disease. Both men and women with coronary artery disease had significantly lower femoral lumen volume and higher roughness values than patients without. Men with previous myocardial infarction had significantly higher mean visual scores of atherosclerosis than those without, while lumen volume and roughness did not differ in either sex. Conclusions. Femoral atherosclerosis is an expression of a generalized disease, associated with clinical symptoms of coronary artery disease. Femoral atherosclerosis is often accompanied by atherosclerosis also in the coronary arteries. |
| Databáze: | OpenAIRE |
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