New Cytochalasin Derivatives from Deep‐Sea Cold Seep‐Derived Endozoic Fungus Curvularia verruculosa CS‐129

Autor:	Xue‐Yi Hu, Xiao‐Ming Li, Sui‐Qun Yang, Bin‐Gui Wang, Ling‐Hong Meng
Rok vydání:	2022
Předmět:	Molecular Structure Cytochalasin B Fungi Humans Molecular Medicine Curvularia Bioengineering General Chemistry General Medicine Cytochalasins Molecular Biology Biochemistry Anti-Bacterial Agents
Zdroj:	Chemistry & Biodiversity. 19
ISSN:	1612-1880 1612-1872
DOI:	10.1002/cbdv.202200550
Popis:	Two new antimicrobial cytochalasin derivatives, 6β,7β-epoxydeoxaphomin C (1) and 12-hydroxydeoxaphomin C (2), a new natural occurring product 24-nor-cytochalasin B (3), together with two related known analogs (4-5) were isolated and identified from an endozoic fungus Curvularia verruculosa CS-129, isolated from the deep-sea squat lobster Shinkaia crosnieri which was collected in cold seep region of south China sea. The structures of new compounds were elucidated on the basis of detailed spectroscopic analysis and ECD calculation. The spectroscopic data of 24-nor-cytochalasin B (3) were reported for the first time. All compounds were tested for their antibacterial activities against human and aquatic pathogenic bacteria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41e05a68840d076905fbe78ee36f11c https://doi.org/10.1002/cbdv.202200550 Zobrazit plný text záznamu Plný text