Determination of oxeladin in human plasma by gas chromatography—mass spectrometry
| Autor: | C. Lartigue-Mattei, J L Chabard, J. M. Aiache, M. J. Galmier, E. Beyssac |
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| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
Detection limit Chromatography Capillary action Chemistry Coefficient of variation Clinical Biochemistry Trimipramine General Medicine Isoamyl alcohol Phenylbutyrates Biochemistry Gas Chromatography-Mass Spectrometry Analytical Chemistry Hexane Antitussive Agents chemistry.chemical_compound Pharmacokinetics Human plasma Drug Discovery Humans Gas chromatography–mass spectrometry Molecular Biology |
| Zdroj: | Biomedical Chromatography. 9:32-35 |
| ISSN: | 1099-0801 0269-3879 |
| DOI: | 10.1002/bmc.1130090107 |
| Popis: | A capillary gas chromatographic method with mass-selective detection was developed for the determination of oxeladin in human plasma. Plasma samples (1 mL) were alkalinized and extracted using 5mL of hexane: isoamyl alcohol (99:1). The method was demonstrated to be sensitive (limit of quantitation at 1 ng/mL), linear between 1 and 150 mg/mL, accurate and precise enough (mean error and mean coefficient of variation at the limit of quantitation were 2.3 and 13.3%, respectively) to support pharmacokinetic evaluation of the drug at doses down to 30 mg. |
| Databáze: | OpenAIRE |
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