The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders
| Autor: | Kais Hussein, Hans Kreipe, Kai Brakensiek, Birgitt Wiese, Jerome Schlue, Thomas Buhr, Oliver Bock |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_treatment Philadelphia Chromosome Negative Mutation Missense Bone Marrow Cells Suppressor of Cytokine Signaling Proteins Biology Suppressor of cytokine signalling law.invention Suppressor of Cytokine Signaling 1 Protein law medicine Humans Philadelphia Chromosome Aged Aged 80 and over Myeloproliferative Disorders Hematology Janus Kinase 2 Middle Aged Hematopoiesis Cytokine medicine.anatomical_structure Gene Expression Regulation Oncology Chronic Disease Immunology Leukocytes Mononuclear Cancer research Suppressor Female Bone marrow Signal transduction Janus kinase Tyrosine kinase |
| Zdroj: | Leukemia Research. 31:799-803 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2006.08.022 |
| Popis: | The suppressor of cytokine signalling-1 (SOCS-1) is a negative regulator of signal transduction mediated by cytoplasmic tyrosine kinases such as the Janus kinases (JAKs). We investigated SOCS-1 expression in bone marrow cells from Philadelphia chromosome negative chronic myeloproliferative disorders (Ph(-) CMPD) and normal haematopoiesis (n=121), and additionally in peripheral blood samples (n=18). Except for chronic idiopathic myelofibrosis harbouring wild-type JAK2, other Ph(-) CMPD expressed significantly higher SOCS-1 levels of up to 14-fold compared to the control group (p0.001) independent of the JAK2 status. The mononuclear cell fraction but not granulocytes in patients with Polycythaemia vera also significantly overexpressed SOCS-1. We conclude that up-regulation of the SOCS-1 gene might reflect a compensatory feedback mechanism with different emphasis among Ph(-) CMPD subtypes independent of an underlying JAK2 (V617F) mutation. |
| Databáze: | OpenAIRE |
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