Testing the veracity of claims of Lewis acid catalysis
| Autor: | Roderick W. Bates, Hong Xuan Lin, Ivan Šolić |
|---|---|
| Přispěvatelé: | School of Physical and Mathematical Sciences |
| Rok vydání: | 2018 |
| Předmět: |
Chemistry::Organic chemistry [Science]
Halogen bond 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Lewis acid catalysis Hydrolysis Lewis Brønsted Drug Discovery Lewis acids and bases Brønsted–Lowry acid–base theory |
| Zdroj: | Tetrahedron Letters. 59:4434-4436 |
| ISSN: | 0040-4039 |
| Popis: | Are reactions employing Lewis acids really catalysed by those Lewis acids, or by “hidden Brønsted acids”, i.e. Brønsted acids generated in situ by hydrolysis? Testing of a series of reactions using Sc(III), Fe(III), In(III) and Y(III) by addition of 2,6-di-t-butyl-4-methylpyridine reveal that all are likely to follow the latter pathway. A reaction claimed to be catalysed by CBr4 through halogen bonding is also likely to be Brønsted acid catalysed. ASTAR (Agency for Sci., Tech. and Research, S’pore) Accepted version |
| Databáze: | OpenAIRE |
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