Increased serum SP-D in identification of high-risk smokers at high risk of COPD
| Autor: | Grith Lykke Sørensen, Fang Wang, Jørgen Vestbo, Kirsten Ohm Kyvik, Christine Dalgård, Ingrid Louise Titlestad |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Risk surfactant protein D Physiology Inflammation Pulmonary Disease Chronic Obstructive Physiology (medical) Smoke medicine Humans tobacco smoking twin study Pulmonary surfactant protein D Lung COPD Innate immune system business.industry Smoking food and beverages Surfactant protein D Cell Biology respiratory system medicine.disease Pulmonary Surfactant-Associated Protein D respiratory tract diseases medicine.anatomical_structure Immunology biomarker Biomarker (medicine) medicine.symptom business Bronchoalveolar Lavage Fluid chronic obstructive lung disease Biomarkers |
| Zdroj: | Dalgård, C, Wang, F, Titlestad, I L, Kyvik, K O, Vestbo, J & Sorensen, G L 2021, ' Increased serum SP-D in identification of high-risk smokers at high risk of COPD ', American journal of physiology. Lung cellular and molecular physiology, vol. 320, no. 6, pp. L1005-L1010 . https://doi.org/10.1152/ajplung.00604.2020 |
| ISSN: | 1522-1504 |
| Popis: | Pulmonary surfactant protein D (SP-D) is an important component of the pulmonary innate immune system with the ability to dampen cigarette smoke-induced lung inflammation. However, cigarette smoking mediates translocation of SP-D from the lung to the blood, and serum SP-D (sSP-D) has therefore previously been suggested as marker for smoke-induced lung injury. In support of this notion, associations between high sSP-D and low lung function measurements have previously been demonstrated in smokers and in chronic obstructive lung disease (COPD). The present investigations employ a 12-yr longitudinal Danish twin study to test the hypothesis that baseline sSP-D variation has the capacity to identify smokers with normal baseline lung function who are at high risk of significant future smoke-induced lung function decline. We find that sSP-D is significantly increased in those with normal lung function at baseline who develop lung function decline during follow-up compared with those who stay lung healthy. Moreover, we demonstrate that it is the smoke-induced baseline sSP-D level, and not the constitutional level, which has capacity as biomarker, and which is linearly increased with the decline in lung function during follow-up. In conclusion, we here present first observation of increased sSP-D for identification of high-risk smokers. |
| Databáze: | OpenAIRE |
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