The Relevance of Selenium Status in Rheumatoid Arthritis
| Autor: | José Francisco Muñoz-Valle, Zyanya Reyes-Castillo, Yolanda Fabiola Márquez-Sandoval, Francisco Javier Turrubiates-Hernández, Guillermo González-Estevez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
rheumatoid arthritis Antioxidant medicine.medical_treatment Population trace elements Nutritional Status lcsh:TX341-641 Inflammation Disease Review medicine.disease_cause Antioxidants Arthritis Rheumatoid 03 medical and health sciences Selenium 0302 clinical medicine Medicine oxidative stress Animals Humans education 030203 arthritis & rheumatology chemistry.chemical_classification education.field_of_study Glutathione Peroxidase Nutrition and Dietetics business.industry Glutathione peroxidase medicine.disease Diet 030104 developmental biology chemistry Rheumatoid arthritis Immunology Dietary Supplements selenoproteins Selenoprotein medicine.symptom Diet Healthy business lcsh:Nutrition. Foods and food supply Oxidation-Reduction Oxidative stress Food Science |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 3007, p 3007 (2020) |
| ISSN: | 2072-6643 |
| Popis: | Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA. |
| Databáze: | OpenAIRE |
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