WW domain-containing oxidoreductase in neuronal injury and neurological diseases
| Autor: | Shur Tzu Chen, Hsin Tzu Chang, Nan Shang Chang, Chan Chuan Liu, Ye Vone Yap, Chun I. Sze |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
WOX1
WWOX Biology neurites WW domain Mice transcription factors medicine Animals Humans Transcription factor Tumor Suppressor Proteins Chromosomal fragile site Neurodegeneration neurodegeneration Wnt signaling pathway Cancer medicine.disease Gerotarget (Focus on Aging): Review neuronal death WW Domain-Containing Oxidoreductase Oncology Cancer research biology.protein Nervous System Diseases Oxidoreductases Neural development |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.2961 |
| Popis: | The human and mouse WWOX/Wwox gene encodes a candidate tumor suppressor WW domain-containing oxidoreductase protein. This gene is located on a common fragile site FRA16D. WWOX participates in a variety of cellular events and acts as a transducer in the many signal pathways, including TNF, chemotherapeutic drugs, UV irradiation, Wnt, TGF-β, C1q, Hyal-2, sex steroid hormones, and others. While transiently overexpressed WWOX restricts relocation of transcription factors to the nucleus for suppressing cancer survival, physiological relevance of this regard in vivo has not been confirmed. Unlike many tumor suppressor genes, mutation of WWOX is rare, raising a question whether WWOX is a driver for cancer initiation. WWOX/Wwox was initially shown to play a crucial role in neural development and in the pathogenesis of Alzheimer's disease and neuronal injury. Later on, WWOX/Wwox was shown to participate in the development of epilepsy, mental retardation, and brain developmental defects in mice, rats and humans. Up to date, most of the research and review articles have focused on the involvement of WWOX in cancer. Here, we review the role of WWOX in neural injury and neurological diseases, and provide perspectives for the WWOX-regulated neurodegeneration. |
| Databáze: | OpenAIRE |
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