Immunoglobulin class and subclass concentrations after treatment of childhood leukemia
| Autor: | Valur Helgi Kristinsson, Jón R. Kristinsson, Olafur Gisli Jonsson, Ásgeir Haraldsson, Arni V Thorsson, Gudmundur K. Jonmundsson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Immunoglobulin A
Adult Time Factors Childhood leukemia Adolescent Immunoglobulins Immunoglobulin E Immunoglobulin G Subclass Leukemia Myelogenous Chronic BCR-ABL Positive Medicine Humans Age of Onset Child Bone Marrow Transplantation Leukemia biology business.industry Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Isotype Leukemia Myeloid Acute Oncology Immunoglobulin M Pediatrics Perinatology and Child Health Immunology biology.protein business Whole-Body Irradiation Follow-Up Studies |
| Zdroj: | Pediatric hematology and oncology. 18(3) |
| ISSN: | 0888-0018 |
| Popis: | With greatly increased survival rates after childhood leukemia during the last 3 decades, the long-term effects of the treatment have become more evident. The disease and its treatment impair the immune system, but the duration of this impairment is unknown. The authors studied the serum concentrations of immunoglobulins and IgG subclasses in 20 Icelandic children cured of leukemia on average 8 years and 3 months after their treatment ended. Although no marked deviations were found in the concentrations of the main immunoglobulin classes IgA, IgM, IgG, and IgE, the IgG subclass levels were below reference values. The patients had on average 0.9 of age standardized reference values of IgG1, 0.5 of IgG2, 0.8 of IgG3, and 0.7 of IgG4. However, none had any autoimmune diseases or a markedly increased tendency for infections. The results indicate that although the immunoglobulin classes regain their normal values within a few years after cessation of treatment, recovery of the IgG subclasses, especially IgG2, is impaired. |
| Databáze: | OpenAIRE |
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