The effect of the antiandrogen II alpha-hydroxyprogesterone on sebum production and cholesterol concentration of sebum
| Autor: | M. Seckelmann, J. Tamm, Erich Ludwig, U. Volkwein |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Sebum production Dermatology Antiandrogen Steroid chemistry.chemical_compound Internal medicine medicine Hydroxyprogesterones Humans Scalp integumentary system Low toxicity Cholesterol Seborrhoeic dermatitis Alopecia Androgen Antagonists Middle Aged Dermatitis Seborrheic body regions Sebum Endocrinology medicine.anatomical_structure chemistry Hydroxyprogesterone Female |
| Zdroj: | The British journal of dermatology. 107(1) |
| ISSN: | 0007-0963 |
| Popis: | SUMMARY IIα-Hydroxyprogesterone, a synthetic antiandrogen of low toxicity, was applied topically. In short-term experiments the sebum production of the forehead in normal male subjects was reduced significantly. The cholesterol concentration of sebum decreased to a greater extent. In long-term studies in patients with seborrhoea and male-pattern alopecia, the steroid caused a marked and constant reduction of greasiness of the hair. In this group also, the cholesterol concentration of the sebvim obtained from scalp hair decreased more markedly than total sebum production. Possible effects of IIα-hydroxyprogesterone on androgenic alopecia are discussed. |
| Databáze: | OpenAIRE |
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