Cytokine profile of food-allergic post-liver transplant children is identified by high levels of IL-5 and low IL-10 secretion from patients' peripheral blood mononuclear cells
| Autor: | Avivit Brener, Ettie Granot, Amit Nahum |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_treatment
Liver transplantation Peripheral blood mononuclear cell Postoperative Complications Immune system Food allergy Humans Medicine Child Interleukin 5 Transplantation business.industry Infant medicine.disease Tacrolimus Interleukin-10 Liver Transplantation Interleukin 10 Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Immunology Leukocytes Mononuclear Cytokine secretion Interleukin-5 business Biomarkers Food Hypersensitivity |
| Zdroj: | Pediatric Transplantation. 19:716-721 |
| ISSN: | 1397-3142 |
| DOI: | 10.1111/petr.12581 |
| Popis: | Severe allergic reaction to food following liver transplantation is a well-known phenomenon. However, the mechanisms underlying this phenomenon are not yet elucidated. This study aimed to reveal the nature of the immune response in post-transplanted allergic patients and compare them to non-allergic transplanted as well as allergic and non-allergic control subjects, with focus on cytokine milieu. Post-liver transplant patients with and without allergic reactions as well as food-allergic but otherwise healthy and healthy non-allergic control patients were recruited. We reviewed patient records and routine laboratory tests and assayed subjects' PBMCs, studying cytokine secretion profile in response to different stimuli. Post-transplant patients with food allergy showed a unique cytokine profile in response to various stimuli, with extremely elevated IL-5, low IL-10 secretion, and somewhat higher IFN-γ. T regulatory cell number was not significantly different among the groups of patients and controls. Immune response of food-allergic post-liver transplant patients is identified by a unique cytokine profile when compared to allergic but otherwise healthy individuals. |
| Databáze: | OpenAIRE |
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