Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma
| Autor: | Danielle Ayr Tavares de Almeida, Claudio Luis Venturini, Domingos Tabajara de Oliveira Martins, Antonio Macho, Karuppusamy Arunachalam, Eduarda Pavan, Suellen Iara Guirra Rosa, Sikiru Olaitan Balogun, Amílcar Sabino Damazo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.drug_class Ovalbumin Vitexin Pharmacology Immunoglobulin E Anti-inflammatory Allergic inflammation 03 medical and health sciences chemistry.chemical_compound Mice medicine Animals Anti-Asthmatic Agents Apigenin Dexamethasone Inflammation biology medicine.diagnostic_test Dose-Response Relationship Drug business.industry General Medicine respiratory system Eosinophil Asthma respiratory tract diseases 030104 developmental biology medicine.anatomical_structure Bronchoalveolar lavage chemistry biology.protein Inflammation Mediators business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 97 |
| ISSN: | 1950-6007 |
| Popis: | Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential as anti-asthmatic. The aim of the present work was to evaluate the anti-hypersensitive activity of vitexin in a murine ovalbumin (OVA)-induced allergic asthma model. Mice were sensitized to OVA by i.p. injection on days 1st and 10th, followed by a daily challenge with OVA using a nebulizer, from days 19th to 24th. Vitexin or dexamethasone were orally administered 1 h before each OVA challenge. Vitexin attenuates migration induced by OVA-hypersensitivity of eosinophil, neutrophil, and mononuclear cells in bronchoalveolar lavage fluid (BALF). Histological analysis of the lungs shows that vitexin suppressed leukocyte infiltration, mucus production and pulmonary edema. Increases in Th2 cytokines in BALF in OVA-induced asthma is also attenuated by vitexin, as well as plasma levels of IgE. Overall, these results suggest that vitexin can suppress OVA-induced allergic inflammation in mice and provide a strong rationale for further developing vitexin as a candidate treatment for allergic hypersensitivity. These data corroborate the popular use of vitexin-rich plants for asthma treatment. |
| Databáze: | OpenAIRE |
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