Network hubs affect evolvability
| Autor: | Jens Frickel, Jana Helsen, Kevin J. Verstrepen, Rob Jelier |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Network architecture General Immunology and Microbiology QH301-705.5 Human evolutionary genetics General Neuroscience Cellular Regulation Gene regulatory network Network structure Biology Affect (psychology) General Biochemistry Genetics and Molecular Biology Evolvability 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Dead end Evolutionary biology Biology (General) General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | PLoS Biology, Vol 17, Iss 1, p e3000111 (2019) |
| Popis: | The regulatory processes in cells are typically organized into complex genetic networks. However, it is still unclear how this network structure modulates the evolution of cellular regulation. One would expect that mutations in central and highly connected modules of a network (so-called hubs) would often result in a breakdown and therefore be an evolutionary dead end. However, a new study by Koubkova-Yu and colleagues finds that in some circumstances, altering a hub can offer a quick evolutionary advantage. Specifically, changes in a hub can induce significant phenotypic changes that allow organisms to move away from a local fitness peak, whereas the fitness defects caused by the perturbed hub can be mitigated by mutations in its interaction partners. Together, the results demonstrate how network architecture shapes and facilitates evolutionary adaptation. ispartof: PLOS BIOLOGY vol:17 issue:1 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|