Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance:Influence of adolescence and psychological stress
| Autor: | Anders Grøntved, Jens Faber, Camilla Fjord Thomsen, Jens P. Goetze, Rasmus Dreier, Tina S Goharian, Mathias Ried-Larsen, Jørgen Jeppesen, Lars Bo Andersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasopressin insulin Adolescent Physiology Population 030209 endocrinology & metabolism Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Copeptin Insulin resistance Internal medicine insulin resistance Humans Medicine Insulin Risk factor Young adult education psychological stress arginine vasopressin education.field_of_study business.industry Depression Glycopeptides copeptin medicine.disease Cross-Sectional Studies Vasopressin secretion Psychological stress depression Homeostatic model assessment Female Arginine vasopressin business Biomarkers Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Thomsen, C F, Dreier, R, Goharian, T S, Goetze, J P, Andersen, L B, Faber, J, Ried-Larsen, M, Grøntved, A & Jeppesen, J L 2019, ' Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance : Influence of adolescence and psychological stress ', Peptides, vol. 115, pp. 8-14 . https://doi.org/10.1016/j.peptides.2019.02.005 Peptides |
| DOI: | 10.1016/j.peptides.2019.02.005 |
| Popis: | In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were log-transformed. Among the young adults, copeptin associated with IR (B (95%CI) = 0.19 (0.11 to 0.27), P |
| Databáze: | OpenAIRE |
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