Pneumocandins from Zalerion arboricola. I. Discovery and isolation
| Autor: | Lauretta Zitano, Raymond F. White, Patrick Gailliot, Robert E. Schwartz, Gerald F. Bills, Carolyn Gleason, P. Salmon, Daniel Kuehner, Kenneth E. Wilson, David F. Sesin, Edward S. Inamine, Kent A. Goklen, August J. Kempf, Henry Joshua |
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| Rok vydání: | 1992 |
| Předmět: |
Microbiological Techniques
Antifungal Agents Microbial Sensitivity Tests Biology Peptides Cyclic Microbiology Hydroxylation chemistry.chemical_compound Echinocandins Biotransformation Biosynthesis Drug Discovery Candida albicans Proline Chromatography High Pressure Liquid Pharmacology Pneumocystis Lipopeptide Fungi imperfecti Ornithine biology.organism_classification Anti-Bacterial Agents chemistry Biochemistry Chromatography Gel Mitosporic Fungi Peptides |
| Zdroj: | The Journal of antibiotics. 45(12) |
| ISSN: | 0021-8820 |
| Popis: | HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline. |
| Databáze: | OpenAIRE |
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