Association Between Cardiotrophin 1 Levels and Central Blood Pressure in Untreated Patients With Essential Hypertension
| Autor: | Eugenia Gkaliagkousi, Stella Douma, Areti Triantafyllou, Eleni Gavriilaki, Fani Chatzopoulou, Konstantinos Petidis, Chrysanthos Zamboulis, Panagiota Anyfanti, Barbara Nikolaidou |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Cardiotrophin 1 Manometry Diastole Blood Pressure Enzyme-Linked Immunosorbent Assay Pulse Wave Analysis Essential hypertension Vascular Stiffness Predictive Value of Tests Internal medicine Internal Medicine medicine Humans Systole Pulse wave velocity business.industry Blood Pressure Monitoring Ambulatory Middle Aged Prognosis medicine.disease Up-Regulation Blood pressure Case-Control Studies Hypertension Arterial stiffness Cardiology Cytokines Female business Biomarkers |
| Zdroj: | American Journal of Hypertension. 27:651-655 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpt238 |
| Popis: | BACKGROUND Cardiotrophin 1 (CT-1) is an interleukin 6-related cytokine recently implicated in cardiac hypertrophy and vascular damage in essential hypertension (EH). We aimed first to determine CT-1 levels in naive, untreated patients with grade I EH (UH) as compared with normotensive (NT) individuals and, second, to investigate a possible association of CT-1 levels with indices of arterial stiffness. METHODS We enrolled 45 consecutive untreated patients recently diagnosed with grade I EH by means of office and ambulatory blood pressure (BP) measurements and 25 age- and sex-matched NT subjects. CT-1 levels were measured with a commercially available enzyme-linked immunosorbent assay kit, and indices of arterial stiffness were determined by applanation tonometry. RESULTS CT-1 levels were significantly elevated in UH patients compared with NT subjects (P < 0.001). Furthermore, CT-1 levels correlated positively with office, ambulatory and central BP. A significant bivariable correlation was also found between CT-1 levels and pulse wave velocity (P = 0.02). In the multivariable analysis, central systolic and diastolic BP proved the only significant predictors of CT-1 levels after controlling for other related factors. CONCLUSIONS To our knowledge, this is the first study that correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension. Thus, studying the effects of CT-1 in the cardiovascular system in patients with EH represents a promising area of investigation in the future. |
| Databáze: | OpenAIRE |
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