A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease
| Autor: | Ehsanollah Esfandiari, Fang-Ping Huang, Xiao-Qing Wei, Max Field, Foo Y. Liew, Iain B. McInnes, Mousa Komai-Koma, George B. M. Lindop |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Mice Inbred MRL lpr Immunology Inflammation urologic and male genital diseases Autoimmune Diseases Proinflammatory cytokine Lesion Mice immune system diseases medicine Animals Humans Lupus Erythematosus Systemic Immunology and Allergy skin and connective tissue diseases Autoimmune disease Lupus erythematosus business.industry Interleukin-18 Glomerulonephritis Middle Aged medicine.disease Interleukin-12 Antibodies Antinuclear Cytokines Female Interleukin 18 medicine.symptom Vasculitis business |
| Zdroj: | The Journal of Immunology. 167:5338-5347 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.167.9.5338 |
| Popis: | Serum from patients with systemic lupus erythematosus (SLE) contained significantly higher concentrations of IL-18 than normal individuals. MRL/lpr mice, which develop spontaneous lupus-like autoimmune disease, also had higher serum levels of IL-18 than wild-type MRL/++ mice. Daily injections of IL-18 or IL-18 plus IL-12 resulted in accelerated proteinuria, glomerulonephritis, vasculitis, and raised levels of proinflammatory cytokines in MRL/lpr mice. IL-18-treated MRL/lpr mice also developed a “butterfly” facial rash resembling clinical SLE. In contrast, MRL/lpr mice treated with IL-18 plus IL-12 did not develop a facial rash. The facial lesion in the IL-18-treated mice showed epidermal thickening with intense chronic inflammation accompanied by increased apoptosis, Ig deposition, and early systemic Th2 response compared with control or IL-12 plus IL-18-treated mice. These data therefore show that IL-18 is an important mediator of lupus-like disease and may thus be a novel target for therapeutic intervention of spontaneous autoimmune diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|