Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology
| Autor: | Johannes Tran-Gia, Michael Lassmann, Susanne Schlögl |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Fabrication Materials science Single Photon Emission Computed Tomography Computed Tomography 3D printing Imaging phantom 030218 nuclear medicine & medical imaging 3d printer 03 medical and health sciences 0302 clinical medicine medicine Calibration Image Processing Computer-Assisted Dosimetry Radiology Nuclear Medicine and imaging Radiometry business.industry Phantoms Imaging Internal radiation Equipment Design 030220 oncology & carcinogenesis Absorbed dose Printing Three-Dimensional Computer-Aided Design Radiology business Biomedical engineering |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 57(12) |
| ISSN: | 1535-5667 |
| Popis: | Currently, the validation of multimodal quantitative imaging and absorbed dose measurements is impeded by the lack of suitable, commercially available anthropomorphic phantoms of variable sizes and shapes. To demonstrate the potential of 3-dimensional (3D) printing techniques for quantitative SPECT/CT imaging, a set of kidney dosimetry phantoms and their spherical counterparts was designed and manufactured with a fused-deposition-modeling 3D printer. Nuclide-dependent SPECT/CT calibration factors were determined to assess the accuracy of quantitative imaging for internal renal dosimetry. Methods: A set of 4 single-compartment kidney phantoms with filling volumes between 8 and 123 mL was designed on the basis of the outer kidney dimensions provided by MIRD pamphlet 19. After the phantoms had been printed, SPECT/CT acquisitions of 3 radionuclides (99mTc, 177Lu, and 131I) were obtained and calibration constants determined for each radionuclide–volume combination. A set of additionally manufactured spheres matching the kidney volumes was also examined to assess the influence of phantom shape and size on the calibration constants. Results: A set of refillable, waterproof, and chemically stable kidneys and spheres was successfully manufactured. Average calibration factors for 99mTc, 177Lu, and 131I were obtained in a large source measured in air. For the largest phantom (122.9 mL), the volumes of interest had to be enlarged by 1.2 mm for 99mTc, 2.5 mm for 177Lu, and 4.9 mm for 131I in all directions to obtain calibration factors comparable to the reference. Although partial-volume effects were observed for decreasing phantom volumes (percentage difference of up to 9.8% for the smallest volume [8.6 mL]), the difference between corresponding sphere–kidney pairs was small ( |
| Databáze: | OpenAIRE |
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