The future of blood‐based biomarkers for Alzheimer's disease
| Autor: | Kim, Henriksen, Sid E, O'Bryant, Harald, Hampel, John Q, Trojanowski, Thomas J, Montine, Andreas, Jeromin, Kaj, Blennow, Anders, Lönneborg, Tony, Wyss-Coray, Holly, Soares, Chantal, Bazenet, Magnus, Sjögren, William, Hu, Simon, Lovestone, Morten A, Karsdal, Michael W, Weiner, Hugo, Vanderstiechele |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Epidemiology Disease Article Cellular and Molecular Neuroscience Developmental Neuroscience Alzheimer Disease medicine Humans Biomarker discovery Intensive care medicine Blood based biomarkers business.industry Health Policy Disease progression medicine.disease Psychiatry and Mental health Interest group Immunology Disease Progression Disease risk Biomarker (medicine) Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease business Biomarkers |
| Zdroj: | Alzheimer's & Dementia. 10:115-131 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Fluid biomarkers of AD currently provide indications of disease stage; however, they are not robust predictors of disease progression or treatment response, and most are measured in cerebrospinal fluid, which limits their applicability. With these aspects in mind, the aim of this article is to underscore the concerted efforts of the Blood-Based Biomarker Interest Group, an international working group of experts in the field. The points addressed include: (1) the major challenges in the development of blood-based biomarkers of AD, including patient heterogeneity, inclusion of the "right" control population, and the blood–brain barrier; (2) the need for a clear definition of the purpose of the individual markers (e.g., prognostic, diagnostic, or monitoring therapeutic efficacy); (3) a critical evaluation of the ongoing biomarker approaches; and (4) highlighting the need for standardization of preanalytical variables and analytical methodologies used by the field. |
| Databáze: | OpenAIRE |
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