Study on the relationship between CXCR3 and its ligands and tubal tuberculosis
| Autor: | Bahetibieke Tuohetaerbaike, Hu Sun, Jing Wang, Jiahui Fan, Ying Li, Liang Wang, Yue Wang, Xiaoqian Shang, Xiumin Ma, Jie Lv |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine China Pathology medicine.medical_specialty Receptors CXCR3 animal structures Tuberculosis H&E stain Ligands Chemokine CXCL9 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Humans General Pharmacology Toxicology and Pharmaceutics Pathological Fallopian Tubes Granuloma biology business.industry Epithelial Cells General Medicine Middle Aged medicine.disease biology.organism_classification Tuberculosis Female Genital Chemokine CXCL11 Chemokine CXCL10 030104 developmental biology medicine.anatomical_structure Immunohistochemistry CXCL9 Female Chemokines business Fallopian tube |
| Zdroj: | Life Sciences. 272:119047 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2021.119047 |
| Popis: | Objective Chemokines play an important role in Mycobacterium tuberculosis infection. We aimed to investigate CXCR3, CXCL9, CXCL10 and CXCL11 to explore the correlation between the severity of tubal tuberculosis and chemokines. Methods 26 patients with tubal tuberculosis diagnosed in our hospital from 2016 to 2019 were selected as the experimental group, and 18 female patients who underwent high-risk pregnancy supervision in our hospital from 2016 to 2018 were selected as the control group. The pathological manifestations of tubal tuberculosis were observed by HE staining, the expressions of CXCR3 and its ligands in fallopian tubes were detected by immunohistochemistry. Results Typical granulomatous structure of tubal tuberculosis was observed by HE staining and most of them were accompanied by massive necrosis in the experimental group, while no granulomatous lesions were found in the control group. The results of immunohistochemical staining showed that CXCR3 and its ligands were expressed in the cytoplasm and nucleus of oviduct epithelial cells and inflammatory cells, in the granuloma area. CXCL9, CXCL10 and CXCL11 were related to the severity of the disease. Key findings CXCR3 and its ligands were positively expressed in tubal tuberculosis, especially CXCL9, CXCL10 and CXCL11 were positively correlated with the severity of fallopian tube disease. Significance It is helpful for clinical diagnosis and treatment detection, and provides a new therapeutic target for the study of female genital tuberculosis in the future. |
| Databáze: | OpenAIRE |
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