Centhaquin attenuates hyperalgesia and non-evoked guarding in a rat model of postoperative pain primarily through α 2B -adrenoceptors
| Autor: | Anil Gulati, Shawn Jung, Shridhar V. Andurkar, Mary G. Leonard |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Adrenergic receptor medicine.medical_treatment Imiloxan (+)-Naloxone Motor Activity Piperazines Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Receptors Adrenergic alpha-2 030202 anesthesiology medicine Animals Saline Pharmacology Analgesics Pain Postoperative Behavior Animal Dose-Response Relationship Drug Naloxone business.industry Imidazoles Antagonist Atipamezole Rats Opioid Hyperalgesia Anesthesia Receptors Opioid medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Pharmacology. 789:81-87 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2016.07.016 |
| Popis: | Centhaquin has been shown to produce antinociception in the mouse hot plate and tail flick assays through the opioid, the α2A and α2B adrenoceptors. Present study was conducted to determine the effects of centhaquin in a rat model of postoperative pain. Involvement of opioid, and adrenergic receptors was assessed by pretreating rats with antagonists at the opioid (naloxone), α2-(atipamezole) or α2B-(imiloxan) adrenergic receptors. Postoperative pain was induced by hind paw plantar incision in male Sprague Dawley rats. Antihyperalgesic effects were determined by measurement of paw withdrawal latencies and withdrawal force, using dynamic von Frey filaments; attenuation of non-evoked guarding was measured by assigning pain scores to spontaneous behaviors. Rotarod test was used to determine motor impairment. Animals received saline, centhaquin or antagonist plus centhaquin. Centhaquin produced dose-dependent antihyperalgesic effect and attenuation of non-evoked guarding behavior, versus saline treated rats (P |
| Databáze: | OpenAIRE |
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