Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression
| Autor: | Chader Henni, Leila Azouaou toualbi, Seba Atmane, Khelfi Abderrezak, Bennoui Abdelghani, Toualbi Chahine, Ballouti Wafa, Adnane Mounir, Arab Medina |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant business.industry medicine.medical_treatment Vitamin E Renal function Inflammation General Medicine vitamin E medicine.disease medicine.disease_cause Gastroenterology Advanced oxidation protein products Clinical Research inflammation Internal medicine medicine In patient medicine.symptom atherosclerosis business Oxidative stress chronic kidney disease Kidney disease advanced oxidation protein products |
| Zdroj: | Archives of Medical Sciences. Atherosclerotic Diseases |
| ISSN: | 2451-0629 |
| Popis: | IntroductionAdvanced oxidation protein products (AOPP) are considered as markers of oxidative stress and inflammation, and highly predictive of atherosclerosis. Vitamin E (Vit-E) is a powerful antioxidant, but no consensus on its effectiveness at the level of AOPP or the process of atherosclerosis has been made. Hence this was the aim of the present study.Material and methodsA longitudinal study was conducted on 205 patients with chronic kidney disease (CKD) and 40 controls. The correlations between AOPP and glomerular filtration rate (GFR) and different biological markers were analyzed. Supra-aortic trunk echo-Doppler was conducted to assess the correlation of AOPP with intima-media thickness. The effects of Vit-E treatment on AOPP levels and atherosclerosis progression were also investigated.ResultsAOPP levels increased in parallel to the alteration of renal functions in CKD patients, compared to the control group (p < 0.05). The mean value of AOPP increased concomitantly with the intima-media thickness (p < 0.05). Furthermore, AOPP mean value was higher in patients with atherosclerotic plaques (p < 0.05) compared to those without plaques. Vit-E treatment stabilized the levels of AOPP but had no effect on the atherosclerotic progression.ConclusionsAOPP were proved to be effective markers of oxidative stress and their high levels help to predict the progression of atherosclerosis. As a powerful antioxidant, Vit-E stabilized the AOPP levels. |
| Databáze: | OpenAIRE |
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