Plasma 5'-nucleotidase activities increase in women with hyperemesis gravidarum
| Autor: | Yoshio Yoneyama, Tsutomu Araki, Takashi Yamada, Hajime Kobayashi, Yasuo Otsubo, Makiko Kato, Hiromitsu Chihara |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Clinical Biochemistry Chorionic Gonadotropin 5'-nucleotidase Human chorionic gonadotropin Hyperemesis gravidarum Pregnancy Internal medicine Hyperemesis Gravidarum medicine Humans 5'-Nucleotidase Progesterone Estradiol business.industry General Medicine medicine.disease Adenosine Endocrinology Estrogen Data Interpretation Statistical Gestation Female business Hormone medicine.drug |
| Zdroj: | Clinical biochemistry. 35(7) |
| ISSN: | 0009-9120 |
| Popis: | To investigate plasma activities of 5'-nucleotidase, a key enzyme in the production of adenosine and evaluate the relationship between changes in 5'-nucleotidase activities and pregnancy-related hormones, estrogen, progesterone and human chorionic gonadotropin (hCG) in women with hyperemesis gravidarum.Plasma 5'-nucleotidase activities and estradiol, progesterone and hCG levels were measured in 21 women with hyperemesis gravidarum and normal pregnancies, matched for age, parity and gestational week.In women with hyperemesis gravidarum, plasma 5'-nucleotidase activities averaged 8.1 +/- 0.6 IU/L, which were significantly increased compared to those in normal pregnant women (5.5 +/- 0.5 IU/L)(p0.05). The increases in plasma 5'-nucleotidase activities were accompanied by elevations of plasma estradiol, progesterone and hCG levels.The increase of plasma 5'-nucleotidase activities may be at least partly attributed to elevations of pregnancy-related hormones, suggesting changes in purine metabolism in women with hyperemesis gravidarum. |
| Databáze: | OpenAIRE |
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