Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival

Autor:	Monika, Hajkova, Tomas, Andrasina, Petra, Ovesna, Tomas, Rohan, Marek, Dostal, Vlastimil, Valek, Lenka, Ostrizkova, Stepan, Tucek, Jiri, Sedo, Igor, Kiss
Rok vydání:	2022
Předmět:	Pharmacology Cancer Research Carcinoma Hepatocellular Liver Neoplasms Humans Reproducibility of Results Prospective Studies Chemoembolization Therapeutic General Biochemistry Genetics and Molecular Biology Research Article
Zdroj:	In Vivo
ISSN:	1791-7549 0258-851X
DOI:	10.21873/invivo.12964
Popis:	Background/Aim: To evaluate the prognostic value of Response Evaluation Criteria In Solid Tumors (RECIST), modified RECIST and volumetric analysis in patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). Patients and Methods: This single-center prospective cohort study included a total of 61 patients with HCC treated by transarterial chemoembolization (TACE). The response of TACE was evaluated on preprocedural and postprocedural CT by two radiologists using RECIST/mRECIST and volumetric response to treatment. Each response assessment method was used to classify the response as progressive disease, stable disease, partial response and complete response. Kaplan-Meier analysis with log-rank test was performed for each method to evaluate its ability to help predict overall survival and progression free survival. Interobserver variability and reproducibility was determined by the Pearson and Spearman correlation coefficients. Results: The median overall survival was 17.1 months and the median progression-free survival was 11.1 months. Volumetric assessment was proved to be a prognostic factor for overall survival (p
Databáze:	OpenAIRE
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