Apelin‐mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis

Autor:	Yihan Zhu, Ying Yang, Hong Bu, Hong Huang, Hongyu Chen, Jingjing Ran, Liwen Qin, Yinyun Ni, Menglin Yao, Tingting Song, Mufeng Li, Yongfeng Yang, Tingting Guo, Ningning Chao, Zhiqing Liu, Weimin Li, Li Zhang
Rok vydání:	2022
Předmět:	Cancer Research Cell Transformation Neoplastic Lung Neoplasms Oncology Carcinogenesis Cell Line Tumor Fatty Acids Humans Apelin HMGA1a Protein General Medicine Sterol Regulatory Element Binding Protein 1 Lipids
Zdroj:	Cancer Science. 113:3722-3734
ISSN:	1349-7006 1347-9032
Popis:	Enhanced fatty acid synthesis provides proliferation and survival advantages for tumor cells. Apelin is an adipokine, which serves as a ligand of G protein-coupled receptors that promote tumor growth in malignant cancers. Here, we confirmed that apelin increased sterol regulatory element-binding protein 1 (SREBP1) activity and induced the expression of glutamine amidotransferase for deamidating high-mobility group A 1 (HMGA1) to promote fatty acid synthesis and proliferation of lung cancer cells. This post-translational modification stabilized the HMGA1 expression and enhanced the formation of the apelin-HMGA1-SREBP1 complex to facilitate SREBP1 activity for lipid metabolism and lung cancer cell growth. We uncovered the pivotal role of apelin-mediated deamidation of HMGA1 in lipid metabolism and tumorigenesis of lung cancer cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f330006c91818913d0c22e1a069305 https://doi.org/10.1111/cas.15515 Zobrazit plný text záznamu Plný text