Human Leukocyte Antigens (HLA) Genes Association in Type 1 Diabetic Nephropathy
| Autor: | Souad Mahgoun, Aissa Boudiba, M.C. Abbadi, Nawel Salhi, Malika Akachouche, Habiba Amroun, Esma Mihoubi, Nabila Attal, Malha Azzouz, Faiza Bouldjennet, R. Raache, Fethi Meçabih, Chafia Touil-Boukoffa |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Endocrinology Diabetes and Metabolism Hla genes Human leukocyte antigen Risk Assessment law.invention Diabetic nephropathy 03 medical and health sciences Young Adult 0302 clinical medicine Gene Frequency law HLA Antigens Risk Factors medicine Immunology and Allergy Humans In patient Diabetic Nephropathies Genetic Predisposition to Disease Allele Polymerase chain reaction Genetic Association Studies business.industry Haplotype Middle Aged Protective Factors medicine.disease HLA-B 030104 developmental biology Diabetes Mellitus Type 1 Haplotypes Case-Control Studies Immunology Female business 030215 immunology |
| Zdroj: | Endocrine, metabolicimmune disorders drug targets. 19(8) |
| ISSN: | 2212-3873 |
| Popis: | Background: Diabetic nephropathy is a common worldwide multifactorial disease where involvement of genetic factors is well etablished. The aim of this study was to investigate the HLA genes implication in the development of type 1 diabetic nephropathy. Methods: We performed a case- control study where one hundred and fifty subjects were examined. Patients were divided in two groups; with and without type 1 diabetic nephropathy. HLA typing was performed using Polymerase Chain Reaction- Sequence Specific Oligonucleotide (PCR- SSO) method. HLA association to clinical phenotype and HLA haplotype analysis was also investigated. Results: HLA B*51 is increased in patients without type 1 diabetic nephropathy (7.14% vs. 0 %, P 0.05). Haplotype analysis also does not reveal any significant association, however, A*02-B*18-DRB1*03-DQA1*05- DQB1*03 haplotype shows a tendency to be associated with the development of diabetic nephropathy (P = 0.05). Conclusion: These results suggest a protective effect of HLA B*51 allele from type 1 diabetic nephropathy. However, further studies are required in order to clarify its potential implication as a protective marker. |
| Databáze: | OpenAIRE |
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