Immunotherapy with partially purified and standardized tree pollen extracts. III. Specific IgE response to the major allergens of alder, birch and hazel pollen during immunotherapy
| Autor: | Janniche H, Henrik Ipsen, Petersen Bn, Henning Løwenstein, Wihl Ja, Munch Ep, Schwartz B |
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| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_treatment
Immunology Biology medicine.disease_cause Immunoglobulin E Alder Trees Radioallergosorbent Test Pollen otorhinolaryngologic diseases medicine Immunology and Allergy Humans Betulaceae Clinical Trials as Topic Hazel pollen Significant difference food and beverages Rhinitis Allergic Seasonal Immunotherapy biology.organism_classification Horticulture Desensitization Immunologic biology.protein Immunoelectrophoresis Two-Dimensional Tree pollen |
| Zdroj: | Allergy. 43(5) |
| ISSN: | 0105-4538 |
| Popis: | Patients allergic to pollen from alder, birch and hazel were hyposensitized during a 3-year period with either birch pollen extract alone (n = 24) or a mixture of one or more of alder, birch and hazel pollen extracts (n = 27). The effect of the treatment was evaluated by RAST and tandem crossed-radioimmunoelectrophoresis (tandem-CRIE). The patient' specific IgE response to the major allergens of alder (Aln g I), birch (Bet v I) and hazel (Cor a I and Cor a II), as measured by tandem-CRIE, and the total specific IgE response, measured by RAST, decreased significantly (Pc less than 0.05) during immunotherapy, irrespective of the extract used during the treatment. There was no significant difference (Pc less than 0.05) between the two treatment groups. The results obtained indicate either that birch pollen extract alone is adequate in the treatment of the studied patient group or the patients had been sensitized towards birch pollen alone. |
| Databáze: | OpenAIRE |
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