High rates of tenofovir failure in a CRF01_AE-predominant HIV epidemic in the Philippines
| Autor: | Lyka Trinidad, Katerina Leyritana, Rontgene M. Solante, Edsel Maurice T. Salvana, Angelo dela Tonga, Nina Theresa Dungca, Patrick R Ching, Raul V. Destura, Rosario Tactacan-Abrenica, Elizabeth Freda O. Telan, Jodor Lim, Marissa M. Alejandria, Lalaine Arcangel, Kevin Mendoza, Noel S. Palaypayon, Genesis May J. Samonte, Brian Schwem, Geraldine Arevalo, Christine Penalosa-Ramos |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Tenofovir Anti-HIV Agents Philippines 030106 microbiology Hiv epidemic Human immunodeficiency virus (HIV) HIV Infections Drug resistance medicine.disease_cause lcsh:Infectious and parasitic diseases 03 medical and health sciences Zidovudine 0302 clinical medicine immune system diseases Internal medicine Drug Resistance Viral Medicine Humans lcsh:RC109-216 030212 general & internal medicine Treatment Failure Epidemics Genotyping High rate business.industry K65R virus diseases HIV General Medicine Viral Load Infectious Diseases Drug Therapy Combination Female business Viral load medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 95, Iss, Pp 125-132 (2020) |
| ISSN: | 1201-9712 |
| Popis: | Background: The Philippines has the fastest growing HIV epidemic in the Asia-Pacific. This increase was accompanied by a shift in the predominant HIV subtype from B to CRF01_AE. Increasing evidence points to a difference in treatment responses between subtypes. We examined treatment failure and acquired drug resistance (ADR) in people living with HIV (PLHIVs) after one year on antiretrovirals (ARVs). Methods: PLHIV maintained on ARVs for one year were recruited. Treatment failure was defined as a viral load of ≥1000 copies/mL. Sanger sequencing for genotyping and drug resistance mutation (DRM) detection was performed on patients failing treatment. Results: 513 PLHIV were enrolled. The most common antiretroviral regimens were TDF+3TC + EFV (269) and AZT+3TC + EFV (155). 53 (10.3%) subjects failed treatment. Among these, 48 (90.6%) had DRMs, 84.9% were subtype CRF01_AE. Tenofovir-based regimens performed worse than zidovudine-based regimens (OR 3.28, 95% CI 1.58–7.52 p |
| Databáze: | OpenAIRE |
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