Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2
| Autor: | Liurong Fang, Huanchun Chen, Chen Tan, Manli Liu, Shaobo Xiao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Serotype
Streptococcus suis serotype 2 Streptococcus suis General Veterinary Microarray biology Microarray analysis techniques Gene Expression Profiling General Medicine Real-Time Polymerase Chain Reaction biology.organism_classification Microbiology Virology Monocytes Cell Line Streptococcal Infections Host-Pathogen Interactions Gene expression Humans THP1 cell line Transcriptome Gene Oligonucleotide Array Sequence Analysis |
| Zdroj: | Veterinary Microbiology. 150:126-131 |
| ISSN: | 0378-1135 |
| Popis: | Streptococcus suis serotype 2 (S. suis 2) is a pathogen responsible for several diseases in both pigs and humans. To gain more insight into the pathogenesis of this organism, an oligonucleotide (oligo)-based microarray was used to investigate gene expression changes in human monocytic cells (THP-1) in response to exposure to S. suis 2 strain SC19. A total of 328 differentially expressed genes were identified. These differentially expressed genes belonged to a variety of functional categories, including genes involved in apoptosis, immunity, signal transduction, chemokine production and the ubiquitin-proteasome system. Our findings can be of interest for future research. |
| Databáze: | OpenAIRE |
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