Fronto-subcortical functional connectivity in patients with schizophrenia and bipolar disorder during a verbal fluency task
| Autor: | Elise Leroux, Nicolas Delcroix, Sonia Dollfus, Anaïs Vandevelde |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Bipolar Disorder Developmental psychology Task (project management) Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Verbal fluency test In patient Bipolar disorder Biological Psychiatry Brain Mapping Language Tests Language production Functional connectivity Brain Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Schizophrenia Case-Control Studies Female Nerve Net Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | The World Journal of Biological Psychiatry. 19:S124-S132 |
| ISSN: | 1814-1412 1562-2975 |
| DOI: | 10.1080/15622975.2017.1349339 |
| Popis: | Impairments in language production are common of schizophrenia (SZ) and bipolar disorder (BD). Identifying distinct functional connectivity (FC) patterns in SZ and BD may provide biomarkers for their diagnoses.Forty-nine participants (15 SZ, 14 BD and 20 healthy controls (HC)) underwent a verbal fluency task consisting of mentally generating verbs in French, alternated with periods of silence. Functional network allowed identifying activation clusters: the medio-frontal cluster (MFC), the left subcortical cluster (LSCC) and the left fronto-lateral cluster (LFLC). FC was calculated between the average blood oxygen level-dependent signal time series in each cluster. Analyses of covariance were performed to test group differences on FC among the three paired-seed regions.SZ presented a significant reduced FC compared to HC within two paired-seed regions between the LFLC and the LSCC and between the MFC and the LSCC while BD were not significantly different from HC. SZ compared to BD exhibited a reduced FC within one paired-seed region between the MFC and the LSCC. There was no group effect between the MFC and the LFLC.A specific medio-prefronto-striato-thalamic functional dysconnectivity may be implicated in the pathophysiology of schizophrenia. This reduced fronto-subcortical FC could be a functional brain biomarker of schizophrenia. |
| Databáze: | OpenAIRE |
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