Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data
| Autor: | Max Bell, Pontus Hedberg, John Karlsson Valik, Ana Requena Mendez, Johan Mårtensson, Hideyuki Tanushi, Anders Ternhag, Robert Dyrdak, Suzanne D. van der Werff, Olof Hertting, Anna Färnert, Fredrik Granath, Pontus Naucler |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty viruses Respiratory Infection 030204 cardiovascular system & hematology medicine.disease_cause Virus 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Influenza Human Medicine pneumonia Humans 030212 general & internal medicine Respiratory system Child Respiratory Tract Infections Retrospective Studies business.industry SARS-CoV-2 Respiratory infection virus diseases COVID-19 Retrospective cohort study respiratory system medicine.disease Hospitals respiratory tract diseases Pneumonia Phenotype Respiratory Syncytial Virus Human Viruses Enterovirus viral infection Rhinovirus business |
| Zdroj: | Thorax |
| ISSN: | 1468-3296 0040-6376 |
| Popis: | BackgroundAn understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investigate such differences in patients positive for SARS-CoV-2 compared with influenza, respiratory syncytial virus (RSV) and other respiratory viruses.MethodsWe performed a retrospective cohort study of hospitalised adults and children (≤15 years) who tested positive for SARS-CoV-2, influenza virus A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal coronaviruses, adenovirus or bocavirus in a respiratory sample at admission between 2011 and 2020.ResultsA total of 6321 adult (1721 SARS-CoV-2) and 6379 paediatric (101 SARS-CoV-2) healthcare episodes were included in the study. In adults, SARS-CoV-2 positivity was independently associated with younger age, male sex, overweight/obesity, diabetes and hypertension, tachypnoea as well as better haemodynamic measurements, white cell count, platelet count and creatinine values. Furthermore, SARS-CoV-2 was associated with higher 30-day mortality as compared with influenza (adjusted HR (aHR) 4.43, 95% CI 3.51 to 5.59), RSV (aHR 3.81, 95% CI 2.72 to 5.34) and other respiratory viruses (aHR 3.46, 95% CI 2.61 to 4.60), as well as higher 90-day mortality, ICU admission, ICU mortality and pulmonary embolism in adults. In children, patients with SARS-CoV-2 were older and had lower prevalence of chronic cardiac and respiratory diseases compared with other viruses.ConclusionsSARS-CoV-2 is associated with more severe outcomes compared with other respiratory viruses, and although associated with specific patient and clinical characteristics at admission, a substantial overlap precludes discrimination based on these characteristics. |
| Databáze: | OpenAIRE |
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