Peripheral nervous system manifestations of Shiga toxin-producing E. coli-induced haemolytic uremic syndrome in children
Autor: | Diletta Domenica Torres, Maria Luigia Lasorella, Maria Chironna, Giuseppe Stefano Netti, Mario Giordano, Elena Ranieri, Luisa Santangelo, Delio Gagliardi, Giovanni Piscopo, Leonardo Milella, Vincenza Carbone, Pasquale Conti, Luciana Losito, Federica Spadaccino, Antonio Trabacca, Elena Bresin |
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Rok vydání: | 2021 |
Předmět: |
Pediatrics
medicine.medical_specialty medicine.medical_treatment Anti-Inflammatory Agents Case Report Methylprednisolone RJ1-570 White matter Polyneuropathies medicine Humans Hemolytic uremic syndrome Enterohemorrhagic Escherichia Coli Child Neurorehabilitation Escherichia coli Infections Rehabilitation Plasma Exchange Shiga-Toxigenic Escherichia coli business.industry Neurological Rehabilitation Immunoglobulins Intravenous Hyporeflexia Eculizumab medicine.anatomical_structure Peripheral nervous system Child Preschool Hemolytic-Uremic Syndrome Female medicine.symptom Complication business medicine.drug |
Zdroj: | Italian Journal of Pediatrics Italian Journal of Pediatrics, Vol 47, Iss 1, Pp 1-8 (2021) |
ISSN: | 1824-7288 |
Popis: | Background The Neurological involvement is the most common extra-renal complication of Shiga toxin-producing E. coli-hemolytic uremic syndrome (HUS) or typical HUS. On brain magnetic resonance examination, main neurological signs encompass acute lesions of the basal ganglia and the white matter, which could usually regress after Eculizumab infusion. In contrast, peripheral nervous system (PNS) manifestations in typical HUS are very rare and, when occurring, they require a careful management of neurological sequelae and an intensive multidisciplinary neuro-rehabilitation program. Case presentation Here, we present two pediatric cases of severe and complicated typical HUS with PNS manifestations who required therapeutic treatment and an intensive multidisciplinary neuro-rehabilitation program. In both cases, PNS manifestations were followed by the recovery from typical HUS-related severe central neurological damage and manifested mainly with marked bilateral motor deficit and hyporeflexia/areflexia in the lower limbs. The peripheral polyneuropathy was treated with immunosuppressive therapy (methylprednisolone boluses, i.v. immunoglobulins, plasma exchange), followed by a prolonged intensive neuro-rehabilitation program. After 8 months of rehabilitation, both patients gained complete functional recovery. Conclusions PNS manifestations during typical HUS are a rare event and potentially leading to severe disability. A timely clinical assessment is mandatory to set up a prompt therapeutic and rehabilitation program and to obtain a complete clinical and functional recovery. |
Databáze: | OpenAIRE |
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