DNA Repair and Systemic Lupus Erythematosus
| Autor: | Matthew J. Burak, Rithy Meas, Joann B. Sweasy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male DNA Repair DNA repair Monozygotic twin Somatic hypermutation Biology Biochemistry Article 03 medical and health sciences 0302 clinical medicine immune system diseases Genetic predisposition medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease skin and connective tissue diseases Molecular Biology Gene Autoimmune disease Systemic lupus erythematosus Family aggregation Cell Biology DNA medicine.disease 030104 developmental biology DNA Repair Enzymes 030220 oncology & carcinogenesis Immunology Mutation Female |
| Popis: | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure that affects at least five million people worldwide. Monozygotic twin concordance and familial aggregation studies strongly suggest that lupus results from genetic predisposition along with environmental exposures including UV light. The majority of the common risk alleles associated with genetic predisposition to SLE map to genes associated with the immune system. However, evidence is emerging that implicates a role for aberrant DNA repair in the development of lupus. Here we summarize our current knowledge of the potential association of lupus with mutations in DNA repair genes. We also discuss how defective or aberrant DNA repair could lead to the development of lupus. |
| Databáze: | OpenAIRE |
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