Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly
| Autor: | Sean D. Mooney, Nik Schork, Yongmei Liu, Tamara B. Harris, Anne B. Newman, Steven R. Cummings, Elsa S. Strotmeyer, Gregory J. Tranah, Kristine Yaffe, Yiqiang Zhao, Shana M. Katzman, Mike A. Nalls |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aging Mitochondrial DNA Peptidyl transferase Genotype Population Neural Conduction Disease Mitochondrion DNA Mitochondrial Nerve conduction velocity Haplogroup Cohort Studies RNA Ribosomal 16S Reaction Time Humans education Aged Genetics education.field_of_study biology Peroneal Nerve Mutation biology.protein Body Composition Female Geriatrics and Gerontology Function (biology) Research Article |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences. 70(11) |
| ISSN: | 1758-535X |
| Popis: | Background. Mitoc hondrial dysfunction is a prominent hallmark of many sensory neuropathies. The purpose of this study was to assess the influence of mitochondrial DNA sequence variation on peripheral nerve function in the population-based Health, Aging, and Body Composition Study. Methods. W e investigated the role of common mitochondrial DNA variation (n = 1,580) and complete mitochondrial DNA sequences (n = 138) on peroneal motor nerve conduction velocity and amplitude, average vibration detection threshold, and monofilament sensitivity. Results. Nominal associations among common mitoc hondrial DNA variants and haplogroups were identified but were not statistically significant after adjustment for multiple comparisons. Sequencebased approaches were used to identify aggregate variant associations across the 16S rRNA (weighted-sum, p = 2E-05 and variable threshold, p = 9E-06) for nerve conduction velocity. Several of these rare 16S variants occurred at or near sites with earlier disease associations and are also in close proximity to the peptidyl transferase center, which is the catalytic center of the 16S rRNA Conclusions. These results suggest that sequence variation related to mitochondrial protein synthesis/assembly is associated with peripheral nerve function and may provide insight into targets for intervention or new clinical strategies to preserve nerve function in late life. |
| Databáze: | OpenAIRE |
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