Contribution to Malaria Transmission of Symptomatic and Asymptomatic Parasite Carriers in Cambodia
| Autor: | Eakpor Piv, Sophy Chy, Nimol Khim, Saorin Kim, Laura Berne, Dysoley Lek, Didier Menard, Amélie Vantaux, Reingsey Samreth, Sovannaroth Siv, Walter R. J. Taylor |
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| Přispěvatelé: | Malaria Molecular Epidemiology, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Xeno Cell Innovations [Plzen, République tchèque], National Center for Parasitology, Entomology and Malaria Control [Phnom Penh, Cambodia] (CNM), National Institute of Public Health [Phnom Penh, Cambodge], Mahidol Oxford Tropical Medicine Research Unit, University of Oxford [Oxford]-Mahidol University [Bangkok], Centre for Tropical Medicine and Global Health [Oxford, UK], Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford [Oxford]-University of Oxford [Oxford], Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Institut Pasteur in Cambodia, France Expertise Internationale 5% initiative (grant no. 12INI211), Rotary Club (grant no. GG1523934), United States Agency for International Development/President’s Malaria Initiative/Centers for Disease Control and Prevention through Malaria Consortium, and Dedonder Clayton (grant no. EC/MAM/N°325/14). A. V. was supported by a postdoctoral fellowship from the International Direction, Institut Pasteur, Paris, France., Malaria Molecular Epidemiology (MMEU), University of Oxford-Mahidol University [Bangkok], University of Oxford-University of Oxford, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Plasmodium vivax Prevalence 0302 clinical medicine Anopheles dirus [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child Immunology and Allergy MESH: Animals 030212 general & internal medicine Malaria Falciparum Child MESH: Plasmodium falciparum Infectivity MESH: Middle Aged biology MESH: Malaria Falciparum Anopheles Middle Aged 3. Good health MESH: Plasmodium vivax Infectious Diseases MESH: Young Adult Female MESH: Mosquito Vectors medicine.symptom Cambodia Adult Plasmodium falciparum 030231 tropical medicine Mosquito Vectors Asymptomatic MESH: Anopheles Young Adult 03 medical and health sciences parasitic diseases Malaria Vivax medicine Animals Humans Parasites MESH: Parasites MESH: Prevalence MESH: Humans business.industry MESH: Cambodia MESH: Malaria Vivax MESH: Adult biology.organism_classification medicine.disease Virology MESH: Male business Asymptomatic carrier MESH: Female Malaria |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2018, 217 (10), pp.1561-1568. ⟨10.1093/infdis/jiy060⟩ Journal of Infectious Diseases, 2018, 217 (10), pp.1561-1568. ⟨10.1093/infdis/jiy060⟩ |
| ISSN: | 0022-1899 1537-6613 |
| Popis: | International audience; Background:Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers.Methods:Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential.Results:By microscopy and real-time polymerase chain reaction, Plasmodium falciparum gametocyte prevalence rates were, respectively, 19.3% (n = 21/109) and 44% (n = 47/109) on day (D) 0 and 17.9% (n = 5/28) and 89.3% (n = 25/28) in recrudescent patients (Drec) (RT-PCR Drec vs D0 P = .002). Falciparum malaria patient infectivity was low on D0 (6.2%; n = 3/48) and in Drec (8.3%; n = 1/12). Direct-membrane feeding assays and SFAs gave similar results. None of the falciparum (n = 0/19) and 3 of 28 Plasmodium vivax asymptomatic carriers were infectious to mosquitoes, including those that were followed up for 2 months. Overall, P. falciparum gametocytemias were low except in a few symptomatic carriers.Conclusions:Only symptomatic falciparum malaria patients were infectious to mosquito vectors at baseline and recrudescence, highlighting the need to detect promptly and treat effectively P. falciparum patients. |
| Databáze: | OpenAIRE |
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