Motor symptom asymmetry in Parkinson's disease predicts emotional outcome following subthalamic nucleus deep brain stimulation

Autor: Florence Le Jeune, Didier Maurice Grandjean, Sophie Drapier, K. N’Diaye, Marc Vérin, Paul Sauleau, Dominique Drapier, Philippe Voruz, Claire Haegelen, Jean-François Houvenaghel, Julie Anne Peron
Přispěvatelé: Université de Genève (UNIGE), Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), CRLCC Eugène Marquis (CRLCC), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Swiss Center for Affective Sciences, University of Geneva [Switzerland], Association France Parkinson, Jonchère, Laurent, Université de Genève = University of Geneva (UNIGE), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), Swiss Center for Affective Sciences (CISA)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Cerebellum
Parkinson's disease
medicine.medical_treatment
Emotions
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Striatum
Audiology
Subthalamic nucleus
Functional Laterality
Behavioral Neuroscience
0302 clinical medicine
ddc:150
Deep brain stimulation
media_common
05 social sciences
Parkinson Disease
Middle Aged
Sadness
ddc:128.37
medicine.anatomical_structure
Treatment Outcome
Emotional prosody
Female
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Psychology
Adult
medicine.medical_specialty
Cognitive Neuroscience
media_common.quotation_subject
Experimental and Cognitive Psychology
050105 experimental psychology
Lateralization of brain function
03 medical and health sciences
medicine
Humans
0501 psychology and cognitive sciences
emotional Prosody
(18)FDG-PET
Aged
[SDV.IB] Life Sciences [q-bio]/Bioengineering
Asymmetry
Recognition
Psychology
medicine.disease
Glucose
Case-Control Studies
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
ddc:618.97
030217 neurology & neurosurgery
Emotional Prosody
Zdroj: Neuropsychologia, Vol. 144 (2020) P. 107494
Neuropsychologia
Neuropsychologia, Elsevier, 2020, 144, pp.107494. ⟨10.1016/j.neuropsychologia.2020.107494⟩
Neuropsychologia, 2020, 144, pp.107494. ⟨10.1016/j.neuropsychologia.2020.107494⟩
ISSN: 0028-3932
1873-3514
Popis: International audience; The objective of this study was to explore the brain modifications associated with vocal emotion (i.e., emotional prosody) processing deficits in patients with Parkinson's disease after deep brain stimulation of the subthalamic nucleus, and the impact of motor asymmetry on these deficits. We therefore conducted 18-fluorodeoxyglucose positron emission tomography scans of 29 patients with left- or right-sided motor symptoms of Parkinson's disease before and after surgery, and correlated changes in their glucose metabolism with modified performances on the recognition of emotional prosody. Results were also compared with those of a matched healthy control group. Patients with more left-sided motor symptoms exhibited a deficit in vocal emotion recognition for neutral, anger, happiness and sadness in the preoperative condition that was normalized postoperatively. Patients with more right-sided motor symptoms performed comparably to controls in the preoperative condition, but differed significantly on fear postoperatively. At the metabolic level, the improvement observed among patients with left-sided motor symptoms was correlated with metabolic modifications in a right-lateralized network known to be involved in emotional prosody, while the behavioral worsening observed among patients with right-sided motor symptoms was correlated with metabolic modifications in the left parahippocampal gyrus and right cerebellum. We suggest that surgery has a differential impact on emotional processing according to motor symptom lateralization, and interpret these results as reflecting the (de)synchronization of the limbic loop in the postoperative condition.
Databáze: OpenAIRE
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