Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes
| Autor: | Robert L. Rosenfield, Kenan Qin, Dianne Deplewski, Nancy Ciletti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Gene isoform
medicine.medical_specialty Very low-density lipoprotein Article Subject Endocrinology Diabetes and Metabolism Peroxisome proliferator-activated receptor Biology PPAR agonist 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Receptor lcsh:RC620-627 030304 developmental biology chemistry.chemical_classification 0303 health sciences Nutrition and Dietetics Cholesterol Peroxisome lcsh:Nutritional diseases. Deficiency diseases Endocrinology chemistry 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) Research Article Food Science Lipoprotein |
| Zdroj: | Journal of Nutrition and Metabolism, Vol 2011 (2011) Journal of Nutrition and Metabolism |
| ISSN: | 2090-0732 2090-0724 |
| Popis: | Lipoprotein delivery of fatty acids and cholesterol is linked with peroxisome proliferator-activated receptor (PPAR) activation in adipocytes and macrophages. We postulated that similar interactions exist in sebaceous epithelial cells (sebocytes) in which PPAR activation induces differentiation. High-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) markedly enhanced sebocyte differentiation above that found with PPAR agonists and were more potent than explicable by their lipid content. The PPARγantagonist GW5393 reduced sebocyte differentiation to all PPAR isoform agonists, HDL and VLDL, suggesting that the lipoprotein effect on differentiation occurs partially through activation of PPARγ. Furthermore, we found that sebocytes expressed a unique pattern of lipogenic genes. Our results demonstrate that HDL and VLDL are the most potent inducers of sebocyte differentiation tested to date, and these actions are partially inhibited by PPAR antagonists. This suggests that substrates provided by lipoproteins are targeted to sebocytes and affect their own disposition via PPAR activation. |
| Databáze: | OpenAIRE |
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