DRD4 and SLC6A3 gene polymorphisms are associated with food intake and nutritional status in children in early stages of development
Autor: | Vanessa Suñé Mattevi, Crisciele Fontana, Silvana Almeida, Paula Dal Bó Campagnolo, Julia P. Genro, Márcia Regina Vitolo |
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Rok vydání: | 2015 |
Předmět: |
Waist
Genotype Dopamine Endocrinology Diabetes and Metabolism Clinical Biochemistry Nutritional Status Physiology Biology Biochemistry Eating Gene Frequency mental disorders medicine Humans Prospective Studies Food science Overeating Child Prospective cohort study 3' Untranslated Regions Molecular Biology Alleles Waist-to-height ratio Dopamine Plasma Membrane Transport Proteins Polymorphism Genetic Waist-Height Ratio Nutrition and Dietetics Receptors Dopamine D4 Dopaminergic Infant Exons medicine.disease Obesity Child Preschool Cohort |
Zdroj: | The Journal of Nutritional Biochemistry. 26:1607-1612 |
ISSN: | 0955-2863 |
Popis: | Variants of dopamine system genes such as the DRD4 and the SLC6A3 genes may be involved in food intake regulation because the dopaminergic system influences food reward. We investigated an association of polymorphisms in the DRD4 (exon 3 VNTR) and SLC6A3 (3'UTR VNTR, rs2550948, rs2652511 and rs1048953) genes with food intake and nutritional status in children. This prospective cohort study recruited 359 children at birth. Dietary data and nutritional status were collected at 1 year, 3-4 years, and 7-8 years of age. The polymorphisms were analyzed using polymerase chain reaction based techniques. Food intake and nutritional status were compared among the different SNP genotypes. In the first year of life, DRD4.7R- children showed higher BMI Z-scores (P=.019) than the DRD4.7R+ cohort. At 3-4 years old, DRD4.7R- and SLC6A3.10R/10R children showed a higher intake of palatable foods (P=.024) and a higher waist circumference (P=.017). The rs1048953 SLC6A3 polymorphism was associated with average daily energy intake (P=.003) at 3-4 years and with a waist-to-height ratio of children at 7-8 years (P=.041). Carriers of high dopamine activity alleles of the VNTRs studied in DRD4 and SLC6A3 genes and carriers of T/T genotype of the variant rs1048953 SLC6A3 can present an increased risk for obesity related to overeating because high dopamine activity can increase the perceived incentive value of food reward. |
Databáze: | OpenAIRE |
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