The effects of plasticizers and titanium dioxide on the properties of poly(vinyl alcohol) coatings

Autor:	Nathaniel T. Hillsborough Becker, Alfred L. Gaertner, Mark S. Gebert, E. R. Hsu
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Titanium Vinyl alcohol Materials science Calorimetry Differential Scanning Chemistry Pharmaceutical technology industry and agriculture Plasticizer Pharmaceutical Science Alcohol General Medicine Polymer Polyethylene glycol Diluent Controlled release Permeability chemistry.chemical_compound chemistry Chemical engineering Plasticizers Polyvinyl Alcohol Tensile Strength Polymer chemistry Titanium dioxide Volatilization
Zdroj:	Pharmaceutical development and technology. 6(2)
ISSN:	1083-7450
Popis:	Poly(vinyl alcohol) has not previously been examined in much detail as a controlled release polymer for use in pharmaceutical formulations. However, this food grade polymer has barrier and tensile properties which make it attractive for such applications. The effects of several diluents and fillers on Poly(vinyl alcohol) (PVAL) coatings have been determined using both mechanical property and water vapor permeability measurements. It has been found that the alcohol ethoxylate Neodol 23-6.5 (CH3(CH2)11-O-(CH2-CH2-O)6-H) acts as a plasticizer for PVAL only up to 15-20 wt% in contrast to 600 molecular weight Polyethylene Glycol (PEG 600), which continuously plasticizes PVAL. The effects of Neodol on PVAL mechanical properties and water vapor permeability at higher concentrations can be explained in terms of Neodol phase separation and has been confirmed with DSC. The inert filler and whitener titanium dioxide (TiO2) monotonically degrades film mechanical properties and increases water vapor permeability of the coating. Attempts to correlate coating dust generated during particle attrition tests with mechanical property measurements were unsuccessful. A correlation between accelerated granule stability and water vapor permeability of the PVAL coating was established.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2002d07ac93d3c3382522a106fc3e59 https://pubmed.ncbi.nlm.nih.gov/11417002 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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