Acyclic Nucleosides Bearing a Furanyl Scaffold
| Autor: | Vasu Nair, Sanjib Bera |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Scaffold
Stereochemistry Chemistry T-Lymphocytes Human immunodeficiency virus (HIV) Substrate (chemistry) HIV Nucleosides Deoxycytidine kinase General Medicine medicine.disease_cause Combinatorial chemistry Antiviral Agents Biochemistry Nucleic acid medicine Genetics Moiety Humans Molecular Medicine Furans |
| Zdroj: | Nucleosides, Nucleotides and Nucleic Acids. 24:37-43 |
| ISSN: | 1525-7770 |
| DOI: | 10.1081/ncn-200046782 |
| Popis: | Synthesis of acyclic nucleosides bearing a furanyl scaffold is described. The approach involved the construction of the base moiety onto a dihydrofuranyl intermediate. While the A and C analogues did exhibit some substrate activity toward deoxycytidine kinase, the compounds were devoid of any significant anti-HIV activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|