Cardiac Autonomic Functions are Altered in Patients with Acute Leukemia, Assessed by Heart Rate Variability
| Autor: | Cem Köz, Oral Nevruz, Türker Çetin, Cemal Sag, Mehmet Yokuşoğlu, Ferit Avcu, Sait Demirkol, Ersoy Isik, Oben Baysan, Ali Uğur Ural, Mehmet Uzun |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Holter monitor Acute myeloblastic leukemia General Biochemistry Genetics and Molecular Biology Electrocardiography Hemoglobins Sex Factors Heart Rate hemic and lymphatic diseases Internal medicine Heart rate medicine Humans Heart rate variability Intensive care medicine Acute leukemia Leukemia medicine.diagnostic_test business.industry Age Factors Case-control study Arrhythmias Cardiac General Medicine medicine.disease medicine.anatomical_structure Case-Control Studies Ferritins Female Bone marrow business |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 211:121-126 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.211.121 |
| Popis: | Acute leukemia is one of the leading malignancies worldwide. Although neuropathy was reported as one of the complications of leukemia, there is a little data about the autonomic involvement. This study was designed to investigate the cardiac autonomic disturbances in acute leukemias by using time-domain indices of heart rate variability (HRV). Newly diagnosed 36 patients with acute leukemia (14 acute lymphoblastic leukemia and 22 acute myeloblastic leukemia) and gender- and age-matched 32 healthy subjects as controls were enrolled in this study. The diagnosis of leukemia was established by whole blood count, peripheral smears and bone marrow aspirations. In order to rule out the effect of any medication on HRV, the patients were selected from those who had not received any antineoplastic agent yet. For assessing the cardiac autonomic functions, HRV obtained from 24-hr Holter monitor recordings was used. The age, gender and serum ferritin levels were similar, while hemoglobin levels were lower in the leukemia group. The comparison of the leukemia group and control group revealed that HRV decreased in patients with acute leukemia, which reflects sympathetic dominance in acute leukemia. This is the first study that shows altered cardiac autonomic functions in patients with acute leukemias who are not on any therapeutical intervention. The altered cardiac autonomic functions may be a sign of paraneoplastic neuropathy in patients with acute leukemia. |
| Databáze: | OpenAIRE |
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