Pilot Clinical Trial of Time-Restricted Eating in Patients with Metabolic Syndrome
| Autor: | Joanna Wróblewska, Simone J. P. M. Eussen, Jarosław Nuszkiewicz, Pam R. Taub, Kristine Færch, Celestyna Mila-Kierzenkowska, Alina Woźniak, Iwona Świątkiewicz, Paweł Rajewski, Karolina Szewczyk-Golec, Emily N. C. Manoogian, Satchidananda Panda |
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| Přispěvatelé: | Epidemiologie, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome |
| Rok vydání: | 2021 |
| Předmět: |
Male
030204 cardiovascular system & hematology Cardiovascular law.invention Eating 0302 clinical medicine Randomized controlled trial law health outcomes education.field_of_study Nutrition and Dietetics digestive oral and skin physiology clinical trial Fasting Middle Aged m-health applications Female time-restricted eating Sleep Research lcsh:Nutrition. Foods and food supply Adult circadian rhythm medicine.medical_specialty cardiometabolic risks Population Clinical Trials and Supportive Activities M-health ap-plications 030209 endocrinology & metabolism lcsh:TX341-641 dietary assessment methodologies Body weight Article metabolic syndrome 03 medical and health sciences Young Adult body weight Food Sciences Clinical Research Intervention (counseling) Internal medicine Behavioral and Social Science medicine Humans In patient eating pattern Circadian rhythm Obesity education Metabolic and endocrine Aged Nutrition business.industry Prevention Feeding Behavior medicine.disease Clinical trial Metabolic syndrome business Sleep Energy Intake Food Science |
| Zdroj: | Nutrients, vol 13, iss 2 Nutrients, Vol 13, Iss 346, p 346 (2021) Nutrients, 13(2):346. Multidisciplinary Digital Publishing Institute (MDPI) Nutrients Światkiewicz, I, Mila-Kierzenkowska, C, Woźniak, A, Szewczyk-Golec, K, Nuszkiewicz, J, Wróblewska, J, Rajewski, P, Eussen, S J P M, Færch, K, Manoogian, E N C, Panda, S & Taub, P R 2021, ' Pilot clinical trial of time-restricted eating in patients with metabolic syndrome ', Nutrients, vol. 13, no. 2, 346, pp. 1-18 . https://doi.org/10.3390/nu13020346 Volume 13 Issue 2 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13020346 |
| Popis: | Metabolic syndrome (MetS) and erratic eating patterns are associated with circadian rhythm disruption which contributes to an increased cardiometabolic risks. Restricting eating period (time-restricted eating, TRE) can restore robust circadian rhythms and improve cardiometabolic health. We describe a protocol of the Time-Restricted Eating on Metabolic and Neuroendocrine homeostasis, Inflammation, and Oxidative Stress (TREMNIOS) pilot clinical trial in Polish adult patients with MetS and eating period of &ge 14 h/day. The study aims to test the feasibility of TRE intervention and methodology for evaluating its efficacy for improving metabolic, neuroendocrine, inflammatory, oxidative stress and cardiac biomarkers, and daily rhythms of behavior for such population. Participants will apply 10-h TRE over a 12-week monitored intervention followed by a 12-week self-directed intervention. Changes in eating window, body weight and composition, biomarkers, and rhythms of behavior will be evaluated. Dietary intake, sleep, activity and wellbeing will be monitored with the myCircadianClock application and questionnaires. Adherence to TRE defined as the proportion of days recorded with app during the monitored intervention in which participants satisfied 10-h TRE is the primary outcome. TREMNIOS will also provide an exploratory framework to depict post-TRE changes in cardiometabolic outcomes and behavior rhythms. This protocol extends previous TRE-related protocols by targeting European population with diagnosed MetS and including long-term intervention, validated tools for monitoring dietary intake and adherence, and comprehensive range of biomarkers. TREMNIOS trial will lay the groundwork for a large-scale randomized controlled trial to determine TRE efficacy for improving cardiometabolic health in MetS population. |
| Databáze: | OpenAIRE |
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