Chronic respiratory symptoms, von Willebrand factor and longitudinal decline in FEV1

Autor: D.A.R. Boldy, J G Ayres, Daniel C. Chambers
Rok vydání: 1999
Předmět:
Zdroj: Respiratory Medicine. 93(10):726-733
ISSN: 0954-6111
DOI: 10.1016/s0954-6111(99)90040-9
Popis: Although some risk factors for accelerated decline in forced expiratory volume in 1 s (FEV1) such as cigarette smoking, are well defined, it is not possible to identify those individuals with the most rapid rates of decline. Von Willebrand factor (vWF) is a product of both the pulmonary and systemic endothelium, and serum levels are raised during episodes of acute bronchitis. We hypothesized that raised serum levels of vWF may indicate sub-clinical pulmonary injury and so may predict subsequent accelerated decline in FEV1. The aims of this study were 1. to define the prevalence of chronic respiratory symptoms and obstructive airway disease in an inner-city British population and 2. to determine whether elevated levels of von Willebrand factor (vWF) identify those individuals at risk for more rapid decline in FEV1 over time. In 1987, all 2013 individuals aged 45 to 74 years at an inner-city general practice were mailed a respiratory symptom questionnaire. One in six of the responders were asked to attend for spirometry and for assessment of serum vWF. In 1996, those individuals who had spirometry and vWF assessed in 1987 were traced, and repeat spirometry was performed. In 1987, 1527 of 2013 (75·8%) individuals completed the questionnaire. Forty-two point two percent of responders reported shortness of breath on hills, 34·7% reported wheeze and 31·6% reported mucus hypersecretion. Smokers were more likely to report these symptoms. Two hundred and ten of the 251 (84%) individuals approached had spirometry and vWF assessed. Eleven percent of these had both an FEV1
Databáze: OpenAIRE
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