Dissecting corollary discharge dysfunction in schizophrenia

Autor:	Judith M. Ford, William O. Faustman, Daniel H. Mathalon, Brian J. Roach, Max Gray
Rok vydání:	2007
Předmět:	Adult Male medicine.medical_specialty Cognitive Neuroscience Experimental and Cognitive Psychology Audiology Developmental psychology Corollary Developmental Neuroscience Group differences Agency (sociology) medicine Humans Speech In patient Evoked Potentials Biological Psychiatry Auditory Cortex Expectancy theory Endocrine and Autonomic Systems Extramural General Neuroscience Data interpretation Electroencephalography medicine.disease Neuropsychology and Physiological Psychology Neurology Schizophrenia Data Interpretation Statistical Calibration Female Schizophrenic Psychology Psychology Photic Stimulation
Zdroj:	Psychophysiology. 44:522-529
ISSN:	1469-8986 0048-5772
DOI:	10.1111/j.1469-8986.2007.00533.x
Popis:	During talking, a corollary discharge prepares cortex for self-generated sounds, minimizing responsiveness and providing a way to recognize sounds as self-generated. When we talk, we are the agent producing the sound and know what sound to expect. The auditory ERP N1 is normally suppressed during talking, but less so in schizophrenia, perhaps due to deficits in agency and expectancy inherent to talking. N1 was assessed in 27 patients (23 schizophrenia, 4 schizoaffective) and 26 controls. During talking, subjects said "ah" every 1-2 s. During agency, subjects pressed a button to deliver "ah" every 1-2 s. During expectancy, "ah" followed a visual warning. Talking yielded greatest N1 suppression in controls and greatest suppression failure in patients. Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc8bf17a593f4f1abb5f4a5510a601 https://doi.org/10.1111/j.1469-8986.2007.00533.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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