Synthesis of forphenicinol and forphenicine

Autor:	Hamao Umezawa, Hajime Morishima, Junji Yoshizawa, Tomio Takeuchi, R. Ushijima
Rok vydání:	1982
Předmět:	Pharmacology Chemical Phenomena Chemistry Stereochemistry organic chemicals Glycine Forphenicine Anti-Bacterial Agents Drug Discovery polycyclic compounds Organic chemistry heterocyclic compounds Oxidation-Reduction Forphenicinol
Zdroj:	The Journal of Antibiotics. 35:1500-1506
ISSN:	1881-1469 0021-8820
DOI:	10.7164/antibiotics.35.1500
Popis:	Forphenicinol, L-2-(3-hydroxy-4-hydroxymethylphenyl)glycine, was synthesized by two methods starting from dimethyl hydroxyterephthalate or DL-2-(3-hydroxyphenyl)glycine. Forphenicine, L-2-(4-formyl-3-hydroxyphenyl)glycine, was prepared from L-forphenicinol by oxidation, thus establishing configuration of forphenicine to be L. D-Forphenicinol was determined to be biologically inactive.
Databáze:	OpenAIRE
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