Impact of dehydroepiandrosterone on clinical outcome in poor responders: A pilot study in women undergoing in vitro fertilization, using bologna criteria
| Autor: | Deepali Atul Bhomkar, Vijayamala Gurudas Gavali, Shruti Mahesh Chougule, Padma Rekha Jirge |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Dehydroepiandrosterone lcsh:Gynecology and obstetrics Human fertilization Poor ovarian response dehydroepiandrosterone supplementation medicine lcsh:RG1-991 Gynecology Pregnancy In vitro fertilisation business.industry medicine.disease live birth rate Pregnancy rate Bologna criteria Reproductive Medicine embryo quality Original Article Gonadotropin Live birth business Embryo quality hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Human Reproductive Sciences, Vol 7, Iss 3, Pp 175-180 (2014) Journal of Human Reproductive Sciences |
| ISSN: | 1998-4766 0974-1208 |
| Popis: | Objective: To evaluate the role of dehydroepiandrosterone (DHEA) supplementation in women with poor ovarian response (POR) undergoing in vitro fertilization (IVF). Design: Prospective case-control study. Setting: Private tertiary fertility clinic. MATERIALS AND Methods: 31 infertile women with POR diagnosed as per the Bologna criteria. Interventions: DHEA supplementation for 2 months and a subsequent IVF cycle, after two previous IVF cycles with POR. Main Outcome Measure(S): Dose and duration of gonadotropin therapy, oocyte yield, embryo number and quality, pregnancy and live birth rate. Results: No difference was seen in gonadotropin requirement before and after DHEA supplementation. There was a significant increase in total and metaphase II oocytes (5.9 ± 0.68 vs. 2.73 ± 0.24; 4.45 ± 0.47 vs. 2.09 ± 0.26), fertilization (3.65 ± 0.49 vs. 2.00 ± 0.27), Grade I embryos (1.52 ± 0.25 vs. 0.55 ± 0.18), pregnancy rate (30% vs. 9.1%) and live birth rate (25% vs 0%) in those who completed the cycle, following DHEA supplementation. Conclusions: Dehydroepiandrosterone supplementation results in an improvement in oocyte yield, embryo quality, and live birth rate in a group of women with POR having undergone at least two previous failures due to POR. |
| Databáze: | OpenAIRE |
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