Micro and nanotechnologies in heart valve tissue engineering
| Autor: | Amir Sanati-Nezhad, Hassan Pezeshgi Modarres, John Saliba, Mohammad R. K. Mofrad, Ahmed A. Bakhaty, Amir Nasajpour, Anwarul Hasan |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Technology Assessment Biomedical Materials science 0206 medical engineering Biophysics Bioengineering Nanotechnology 02 engineering and technology Biomaterials Organ Culture Techniques Heart valve tissue engineering Tissue engineering Lab-On-A-Chip Devices medicine Humans Heart valve Tissue engineered Bioartificial Organs Tissue Engineering Tissue Scaffolds technology industry and agriculture Equipment Design 021001 nanoscience & nanotechnology Heart Valves 020601 biomedical engineering medicine.anatomical_structure Mechanics of Materials Ceramics and Composites Nanoparticles 0210 nano-technology Biomedical engineering |
| Zdroj: | Biomaterials. 103:278-292 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2016.07.001 |
| Popis: | Due to the increased morbidity and mortality resulting from heart valve diseases, there is a growing demand for off-the-shelf implantable tissue engineered heart valves (TEHVs). Despite the significant progress in recent years in improving the design and performance of TEHV constructs, viable and functional human implantable TEHV constructs have remained elusive. The recent advances in micro and nanoscale technologies including the microfabrication, nano-microfiber based scaffolds preparation, 3D cell encapsulated hydrogels preparation, microfluidic, micro-bioreactors, nano-microscale biosensors as well as the computational methods and models for simulation of biological tissues have increased the potential for realizing viable, functional and implantable TEHV constructs. In this review, we aim to present an overview of the importance and recent advances in micro and nano-scale technologies for the development of TEHV constructs. |
| Databáze: | OpenAIRE |
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