Hypoglycemia in mitochondrial disorders
| Autor: | Hope Northrup, Mary Kay Koenig, S. Shahrukh Hashmi, Allison R. Moats, Myla Ashfaq, Michael B. Bagg, Claire N. Singletary, David F Rodriguez-Buritica |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Mitochondrial Diseases endocrine system diseases Mitochondrial disease Mitochondrion Hypoglycemia Cohort Studies 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Humans Molecular Biology business.industry nutritional and metabolic diseases Cell Biology medicine.disease 030104 developmental biology Endocrinology Molecular Medicine Female business 030217 neurology & neurosurgery |
| Zdroj: | Mitochondrion. 58:179-183 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2021.03.002 |
| Popis: | Diabetes and hyperglycemia are common features of mitochondrial disorders. This study investigates the frequency of non-iatrogenic hypoglycemia in individuals with these disorders. Of 116 patients, 22 (18.97%) experienced at least two episodes of hypoglycemia. This rate is significantly higher (p 0.05) than the 6% seen in the non-diabetic, general population. Neonatal readings were 30 mg/dL lower than non-neonatal readings. As hypoglycemia appears to occur frequently in individuals with mitochondrial disorders, with lower blood glucose levels in the neonatal period, early and continued monitoring of blood glucose is necessary. Also, mitochondrial disorders should be considered in cases of recurrent hypoglycemia. |
| Databáze: | OpenAIRE |
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