Comparative efficacy of different methods of nebulising terbutaline
| Autor: | A. Bundgaard, J. Z. Pedersen |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.drug_class Terbutaline Dosage form Intermittent Positive-Pressure Ventilation Random Allocation Bronchodilator medicine Humans Pharmacology (medical) Maximal Expiratory Flow Rate Pharmacology Aerosols Inhalation business.industry General Medicine Middle Aged Asthma Aerosol Intermittent positive pressure ventilation Bronchodilatation Evaluation Studies as Topic Anesthesia Female business medicine.drug |
| Zdroj: | European journal of clinical pharmacology. 25(6) |
| ISSN: | 0031-6970 |
| Popis: | The efficacy of terbutaline inhaled from different aerosol systems was studied in 13 adult asthmatics. Terbutaline 1 mg was delivered from a pressurised aerosol, 1 and 4 mg were inhaled from a nebuliser, 1 mg was inhaled through a pressurised aerosol with a pear-shaped, 750 ml spacer, and 1 mg was inhaled from a nebuliser with Intermittent Positive Pressure Ventilation (I.P.P.V.). An open, randomized, cross-over design was used. The bronchodilator effect was evaluated by recording hourly flow-volume curves and the FEV1.0 for 5 h after treatment. No significant difference in bronchodilatation was observed after inhalation of 1 mg terbutaline from different aerosol systems, except following use of the nebuliser, which required approximately four times as much terbutaline to obtain the same effect as the ordinary spray. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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